Test Overview
Sequence Specific Oligonucleotide Polymorphism (SSOP) and Next Generation Sequencing (NGS).
Hematopoietic Cell Transplant (HCT) recipients and respective donors are typed for HLA-A, -B, -DRB1 by low resolution (antigen level) molecular methods. If matched with recipient, donors are typed by high resolution (allele level) molecular to include the following loci: HLA-A, -B, -DRB1, -DRB3/4/5, -DQB1, -DQA1, -DPB1, -DPA1.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Test Details
3 - 10 days
- Bone Marrow Transplant Donor
- New Donor, HC Tx
- HCTND
- HLA Class I Low Resolution
- HLA Class II Low Resolution
- HLA REPORT
- HLBML
- TTYPE
- TISSUE TYPING
Specimen Requirements
Collect specimen in sufficient yellow top (ACD) solution A tubes. Send intact specimen at room temperature. Do not refrigerate or freeze.
Specimens that are not properly labeled with 2 identifiers will be rejected.
Insufficient sample amounts will be rejected.
Additional Information
By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Hematopoietic cell transplants (HCT) is a potentially curative therapy for cancers of the blood and bone marrow, including leukemias, lymphomas, and multiple myeloma. Use of HCT has increased as new techniques have allowed for transplantation in patients who previously would not have been considered HCT candidates. Among the most important factors that affect the outcome of the HCT is the degree of human leukocyte antigen (HLA) matching between the recipient and the related or unrelated donor, or cord blood unit. HLA matching plays an important role in engraftment, occurrence and severity of graft-versus-host disease (GVHD) and overall survival.