Test Overview
Test Methodology

Kinetic Spectrophotometry

Test Usage

Evaluation of neonatal hyperbilirubinemia, favism or chronic or episodic hemolysis or jaundice
Evaluation for gamma-glutamylcysteine synthetase deficiency (OMIM 230450)
Evaluation for glutathione synthetase deficiency causing hemolytic anemia (OMIM 231900)
Evaluation for generalized glutathione synthetase deficiency with 5-oxoprolinuria (OMIM 266130)

Reference Range *

> or =12 months: 46.9-90.1 mg/dL RBC. Reference values have not been established for patients who are <12 months of age.

Test Limitations

Samples with white blood cell counts greater than 20x10(9)/L have been shown to falsely increase the glutathione level by as much as 25%. Results in the normal or elevated range should be interpreted with caution if high white blood cell count is noted. Recent transfusion may mask the patient's intrinsic enzyme activity and cause unreliable results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

10 days

Soft Order Code
GSH
MiChart Code
Glutathione
Laboratory
Sendout
Reference Laboratory
Mayo GSH
Section
Special Testing
Specimen Requirements
Collection Instructions

Draw specimen in ACD solution B tube. Send intact whole blood refrigerated.

Normal Volume
6 mL ACD whole blood
Minimum Volume
1 mL ACD whole blood
Additional Information

Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
82978
Fee Code
AA926
NY State Approved
No