Update Type: Test Resumed
Test Updated: 03/15/2023
Test Overview
Test Methodology


Test Usage

Supporting diagnosis of neurological diseases - primarily motor neuron disease and motor neuropathies.

Reference Range *

Profile Information:
IGG_M: Negative, IGM_M: Negative, IGG_A: Negative, IGM_A: Negative, IGG_D: Negative, IGM_D: Negative

Reflex Information:
IGMTS: <1:2000, IMMTS: <1:4000, IGATS: <1:16000, IMATS: <1:8000, IGDTS: <1:2000, IMDTS: <1:2000

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Titer values of 1:250-1:2000 (modest elevations) are found in 5% of patients with motor neuron disease. Patients with ALS may have modest elevations. High titers have been found only in patients with multifocal motor neuron neuropathy.

Test Details
Days Set Up
Monday, Wednesday
Analytic Time

6 - 9 days days

Soft Order Code
  • Monosialo GM1 Antibodies
  • Asialo GM1 Antibodies
  • Disialo GD1b Antibodies
  • Co-GM1 Triad Antibody Test
  • Motor Neuropathy Antibody
  • GM1B
Reference Laboratory
Mayo GM1B (83189)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume
1 ml serum
Minimum Volume
0.5 ml serum
Storage Temperature
Refrigerated preferred, frozen acceptable
Additional Information

Screening tests are performed for IgG and IgM antibodies to GM1 and GD1b. If positive, the appropriate titer will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.

CPT Code
83516 x6
Fee Code
AA500 x6
Reflex CPT
83520 each
Reflex Fee Code
20081 each