Routine testing is performed by the complement fixation method. Immunodiffusion methodology will be used to resolve questions of cross-reactivity, if the specimen has anti-complementary antibodies or if specifically requested in suspected cases of blastomycosis.
To obtain serologic evidence of an immune response (antibody production) to Histoplasma capsulatum, Blastomyces dermatitidis, or Coccidioides immitis.
Negative. A four-fold or greater rise in titer between acute and convalescent paired specimens, collected 14-21 days apart is consistent with the diagnosis of recent infection. In the presence of high titer against one fungal pathogen, other low level antibody titers may represent a cross-reaction and are not considered significant.
1 - 3 weeks
- Blastomyces Antibody
- Coccidioides Antibody
- Histoplasma Antibody
- Blastomyces Ab, Serum.
- Coccidioides Ab, Serum.
- Histoplasma Ab, Serum.
- Fungal Serology Panel, Serum
MLabs client requests for this test will be sent to Mayo Medical Laboratories.
Plasma is NOT acceptable. Contaminated, grossly hemolyzed or chylous specimens are unacceptable for testing and will be reported as unsatisfactory.
Test sent to Michigan Department of Health & Human Services (MDHHS); although there is no charge for testing, MLabs charges a handling fee for processing and forwarding specimens to MDHHS.