Test Overview

Test Methodology

Routine testing is performed by the complement fixation method. Immunodiffusion methodology will be used to resolve questions of cross-reactivity, if the specimen has anti-complementary antibodies or if specifically requested in suspected cases of blastomycosis.

Test Usage

To obtain serologic evidence of an immune response (antibody production) to Histoplasma capsulatum, Blastomyces dermatitidis, or Coccidioides immitis.

Reference Range*

Negative. A four-fold or greater rise in titer between acute and convalescent paired specimens, collected 14-21 days apart is consistent with the diagnosis of recent infection. In the presence of high titer against one fungal pathogen, other low level antibody titers may represent a cross-reaction and are not considered significant.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Soft Order Code


MiChart Code

Fungal Serology Panel, CSF



Blastomyces Antibody, CSF
Coccidioides Antibody, CSF
Histoplasma Antibody, CSF
Blastomyces Ab, CSF.
Coccidioides Ab, CSF.
Histoplasma Ab, CSF.
Fungal Serology Panel, CSF

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Specimen Requirements

Offsite Collection Instructions

MLabs client requests for this test will be sent to Mayo Medical Laboratories.

Rejection Criteria

Testing for the same test and source is not approved for specimens collected less than 7 days apart.

Normal Volume

4 mL CSF

Minimum Volume

3 mL CSF

Additional Information

Test sent to Michigan Department of Health & Human Services (MDHHS); although there is no charge for testing, MLabs charges a handling fee for processing and forwarding specimens to MDHHS.

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