Test Overview
Test Methodology

Immunoassay

Test Usage

This assay detects Filaria IgG4 associated with infections caused by the major filarial parasites, including Dirofilaria immitis, Wuchereria brancrofti, Brugia malayi, and Onchocerca volvulus.
Chronic filarial infections manifesting as elephantiasis may not show a significant IgG4 response and cannot be ruled out using this test. Samples containing antibodies to other nematodes,
particularly Strongyloides, may cross-react in the assay.

Reference Range *

<2.50 index

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

This assay was developed for the detection of IgG4 subclass antibody to enhance specificity without sacrifice of sensitivity. Antigens of Dirofilaria immitis are employed that serologically crossreact with all filarial species, including W. bancrofti, B. malayi and O. volvulus. Chronic elephantiasis may not result in a significant IgG4 antibody response and cannot be ruled out by this test.

Test Details
Days Set Up
Wednesday
Analytic Time

4 - 22 days

Soft Order Code
MMLR
Synonyms
  • Microfilaria Antibody
  • Brugia sp. Antibody
  • Wuchereria bancrofti Antibody
  • Onchocerca volvulus Antibody
  • Mansonella Antibody
  • Loa loa Antibody
Laboratory
Sendout
Reference Laboratory
Mayo FFAG4 (57875) (Quest 34168)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Storage Temperature
Refrigerated preferred, ambient or frozen acceptable
Additional Information

Test sent to Mayo Medical Laboratories; performed by Quest Diagnostics.

Billing
CPT Code
86682
LOINC
14208-3
NY State Approved
No