Test Overview
Modified Clauss
Identification of congenital afibrinogenemia, disseminated intravascular coagulation, and fibrinolytic activity.
150 - 450 mg/dL. Critical value:
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Increased in patients on oral contraceptives, pregnancy, or with active inflammatory processes. May be decreased in disseminated intravascular coagulation, severe liver disease, and congenital hypofibrinogenemia. Fibrinogen is insensitive to unfractionated heparin up to approximately 2 units/mL. Direct thrombin inhibitors (Argatroban, Bivalarudin, Dabigatran, etc.) in therapeutic doses with result in decreased fibrinogen levels.
Test Details
STAT 1 hour, Routine 4 hours
- Clottable Fibrinogen
- Fibrinogen Activity
- Fibrinogen Level
- Quantitative Fibrinogen
- FIB
- NCFIB
- FIBRINOGEN (CLOTTABLE)
- FIBRINOGEN NO CHARGE
STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).
Specimen Requirements
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.