Test Overview
Test Methodology

Modified Clauss

Test Usage

Identification of congenital afibrinogenemia, disseminated intravascular coagulation, and fibrinolytic activity.

Reference Range *

150 - 450 mg/dL. Critical value:

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Increased in patients on oral contraceptives, pregnancy, or with active inflammatory processes. May be decreased in disseminated intravascular coagulation, severe liver disease, and congenital hypofibrinogenemia. Fibrinogen is insensitive to unfractionated heparin up to approximately 2 units/mL. Direct thrombin inhibitors (Argatroban, Bivalarudin, Dabigatran, etc.) in therapeutic doses with result in decreased fibrinogen levels.

Test Details
Days Set Up
Daily, 24 hours
Analytic Time

STAT 1 hour, Routine 4 hours

Soft Order Code
FIB
MiChart Code
Fibrinogen
Synonyms
  • Clottable Fibrinogen
  • Fibrinogen Activity
  • Fibrinogen Level
  • Quantitative Fibrinogen
  • FIB
  • NCFIB
  • FIBRINOGEN (CLOTTABLE)
  • FIBRINOGEN NO CHARGE
Laboratory
Hematopathology
Section
Coagulation
STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

Specimen Requirements
Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Rejection Criteria
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, or contaminated with heparin
Blue Top Tube
Normal Volume
Full 2.7mL tube or 1mL plasma aliquot
Minimum Volume
Full 1.8mL tube or 1mL plasma aliquot
Storage Temperature
Room temperature for whole blood or frozen aliquot of citrated plasma.
Billing
CPT Code
85384
Fee Code
31107
LOINC
3255-7
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