Days Set Up
Monday - Friday
Analytic Time

1 day

MiChart Code
Extractable Nuclear Antibodies, Sm and RnP
Soft Order Code
SMRN

Test Updated:

Synonyms

Smith Antibody
Anti-SmRNP
Anti-Sm (Smith)
RNP Antibody
SmRNP Antibody
U1RNP Antibody
SMRN
ANTI-SmRNP
ANTI-RNP
RNP
ANTI-SM
SMITH
Sm (Smith) Antibody
SMRNP
ENA (ANTI-Sm/SmRNP/RNP)
ENA 3 Antibody Panel
Anti-RNP (Ribonucleoprotein)
EXTRACTABLE NUCLEAR ANTIBODY

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Test Overview

Test Methodology

Multiplex Flow Immunoassay

Test Usage

Antibodies to the Sm antigen represent a highly specific marker for SLE, but only occur in 25 - 35% of patients with the disease. Antibodies to RNP occur in 30 - 40% of patients with SLE, but are not specific for SLE. Antibodies to RNP are present in nearly all patients with Mixed Connective Tissue Disease (MCTD), and are specific for this disorder when all other antibodies are negative. The Sm and RNP antigens are closely associated, part of a protein and small nuclear RNA complex. The Bioplex 2200 ANA screen test system has beads coated with affinity purified Sm, with recombinant antigens RNP-68 and RNP-A, and a separate bead coated with Sm/RNP combined purified antigen.

Reference Range

Negative

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.25 mL serum

Billing Information

CPT Code
86235 x3
Pro Fee Code
 
Insurance Auth Info
 
LOINC
Z260-0 SMRN, 31627-3 SMITH, 31628-1 SMRNP, 8091-1 RNP

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.