Gas Chromatography (GC)
Monitor therapeutic drug levels
40-100 mcg/mL, Toxic > 150 mcg/mL.
- ETHOSUXIMIDE LEVEL
Collect blood in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial, and refrigerate. Heparinized or EDTA plasma is also acceptable.
Ethosuximide levels fluctuate little from day to day with regular medication intake. Timing of samples is not critical. Half-life is 30 hours for children and 60 hours for adults.