Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time
MiChart Code
ERG Rearrangement by FISH (cytogenetics)
Soft Order Code

Test Updated:


ERG gene region 21q22
Prostatic Adenocarcinoma
Prostate Cancer

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Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects rearrangements involving the ERG gene region (21q22) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of ERG rearrangements that are associated with a subset of prostatic adenocarcinoma. Testing for ERG gene rearrangement may aid in: 1. Diagnosis and classification of a subset of prostatic adenocarcinoma 2. Diagnosis and classification of a subset of neuroendocrine prostate cancer 3. Confirmation of presence or absence of ERG gene rearrangement in prostatic adenocarcinoma cases with equivocal ERG immunohistochemical expression. 4. Differential diagnosis of poorly differentiated prostate cancer versus poorly differentiated urothelial cancer 5. Diagnosis of ERG positive metastatic prostatic adenocarcinoma 6. Diagnosis of ERG positive prostatic adenocarcinoma with low or equivocal ERG immunohistochemical expression (for example, treated prostate cancer).

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Submit a formalin-fixed, paraffin block of the tumor tissue (with matched benign prostate tissue if available); store at room temperature.

Minimum Volume

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.