Multiplex Flow Immunoassay
Support diagnosis of EBV infection.
NEGATIVE: Indicates no detectable IgG antibody to EBV Early Antigen; EQUIVOCAL: Presence or absence of IgG antibody to EBV Early Antigen cannot be determined. Another specimen should be sent for analysis; POSITIVE: Indicates detectable levels of IgG antibody to EBV Early Antigen.
Assay performance characteristics have not been established for immunocompromised or immunosuppressed patients, cord blood, neonatal specimens or infants. Assay performance characteristics have not been established for the diagnosis of nasopharyngeal carcinoma, Burkitt’s lymphoma and other EBV-associated lymphomas.
- EBV Early Antigen, IgG
Collect specimen in SST tube.
Centrifuge, aliquot serum into a plastic vial and refrigerate.
IgG antibodies to EA-D are frequently present in acute IM and generally absent in convalescence. A rise may indicate acute infection, reactivation or chronic infection. The presence of antibodies in other healthy individuals usually indicates reactivation, especially when paired with rising EBNA-1 levels. Antibody levels tend to rise and peak after 3-4 weeks, then decline and usually dissipate after 6 months.