Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Therapeutic drug monitoring.
Encainide: 15 - 100 ng/mL; O-desmethylencainide (ODE): 100 - 300 ng/mL; 3-methoxy-ode (MODE): 60 - 300 ng/mL. Ten percent of patients do not form therapeutic levels of the active metabolites MODE and ODE. In these patients, the recommended range for encainide is 300 - 1,200 ng/mL.
4 - 8 days
- ENCAINIDE (ENKAID)
- 3-METHOXY-ODE (MODE)
- O-DEMETHYLENCAINIDE (ODE)
Collect blood in a red or green top tube; do not use SST/PST tube. Centrifuge, aliquot serum or plasma into plastic vial and refrigerate.
Test sent to Mayo Medical Laboratories; performed by MedTox Laboratories.