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Mutations affecting EGFR occur in approximately 10-20% of non-small cell lung cancers (NSCLC). The particular mutation(s) present within neoplastic cells affects the predicted response to specific targeted therapies including EGFR-directed treatments. This DNA test is performed by targeted next-generation sequencing (NGS) and will detect EGFR mutations within the sequenced regions of exons 3, 7, 12, 15, and 18-21. Specimens should contain an adequate proportion of neoplastic cells (>20%) in the area to be extracted to ensure mutation detection.
Interpretive Report Provided
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
For formalin-fixed, paraffin-embedded tissue, a block containing an area with a high percentage of neoplastic cells (for micro-/macro-dissection) is preferred. Unstained, UNBAKED slides (5-8, 10-micron slides; 10-15 if few neoplastic cells are present) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature. A Diff-Quik or Papanicolaou stained aspirate smear (preferable containing a high percentage and overall amount of neoplastic cells) is also acceptable. Store at room temperature.