Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Monitor therapeutic drug levels; monitor patient compliance; evaluate doxepin toxicity
Therapeutic: 75-200 ng/mL; Toxic: > 500 ng/mL; Lethal: 1000 ng/mL (sum of Doxepin and Desmethyldoxepin).
- Tricyclics, Doxepin
- DOXEPIN AND DEMETHYLDOXEPIN
- Doxepin and Nordoxepin
- DOXEPIN RESULT
- DOXEPIN & DEMETHYLDOXEPIN LEV
- DOXEPIN + DEMETHYLDOXEPIN LEV
Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.
Doxepin is a tricyclic antidepressant that has been reported to have less cardiotoxicity than the other TADs. Desmethyldoxepin, the metabolite of doxepin, is also measured.