In high titer, marker antibody for systemic lupus erythematosus (SLE). Monitor clinical course and response to treatments, especially in patients with nephritis. Anti-dsDNA titers do not correlate with disease activity in all patients.
<27 IU/mL (Negative); 27 - 35 IU/mL (Borderline Positive); >=36 IU/mL (Positive).
- Anti-DNA Double Stranded (EIA)
- Double-Stranded DNA Antibody
- Native DNA Antibody
- ANTI-dsDNA ANTIBODY
Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic tube and refrigerate for up to 7 days or freeze for longer storage.
Significant elevations are specific for antibodies to Double-Stranded DNA and are highly suggestive of systemic lupus. Weakly positive tests may be due to cross-reactivity with antibody to Single-Stranded DNA or may occassionally be seen in rheumatoid arthritis and other connective tissue diseases. Clinical correlation, including the results of ANA and ENA testing, is important.