Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time
MiChart Code
Cytogenetics, ALL FISH Panel
Soft Order Code

Test Updated:


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Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

The ALL FISH Panel is used for the detection of recurrent chromosome abnormalities observed in infants and children with B-cell lymphoblastic leukemia/lymphoma. Identification of specific abnormalities helps predict disease aggressiveness and response to therapy. The B-ALL FISH panel includes: 1) ETV6/RUNX1 probe, to detect t(12;21); this translocation is often cryptic by chromosome analysis. 2) BCR/ABL + ASS dual-fusion probe, to detect t(9;22) and variants. 3) MLL break-apart probe, to detect MLL (11q23.3) rearrangement; the specific rearrangement partner chromosome is not interrogated by FISH. 4-6) CEP 4/CEP 10/ CEP 17 enumeration probes, to detect hyperdiploidy involving trisomies of chromosomes 4, 10 and 17. Reflex testing for Xp22.3/Yp11.3 rearrangement (CRLF2) and/or 9p24 rearrangement (JAK2) may be performed after Chromosome Analysis and Cancer Cytogenomics Array testing, if clinically indicated.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

ALL FISH testing is performed as an adjunct to Chromosome Analysis when appropriate using the specimen submitted for Chromosome Analysis, unless otherwise approved by the Cytogenetics Laboratory Director. Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. See "Cytogenetics, Chromosome Analysis, Bone Marrow" or "Cytogenetics, Chromosome Analysis, Blood for Malignancy" for specimen collection and handling requirements.

Normal Volume
5 mL whole blood or 2 mL bone marrow
Minimum Volume
2 mL whole blood or bone marrow; additional specimen may be required for patients with extremely low white cell counts or on COG study.

Billing Information

CPT Code
88237, 88271 x5, 88275 x7
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.