Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time
MiChart Code
Cytogenetics, FISH for Malignancy
Soft Order Code

Test Updated:


ETV6/RUNX1 (TEL/AML1) t(12;21)
FGFRI (8p11.2)
BCR/ABL t(9;22)
PML/RARA t(15;17)
MLL t(11q23)
IGH/CCND1 t(11;14)
FISH Oncology Probes
PDGFRB (5q32)
RUNX1/RUNX1T1 t(8;21)
CBFB/MYHII inv(16)
CHIC2 deletion, FISH Probe
PDGFRA/FIP1L1 (4q12)
PDGFRA Translocation Detection by FISH
FISH for Neoplasia

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

Oncology probes are useful for assisting in diagnosis and classification of malignant hematologic disorders and certain solid tumors, evaluating prognosis and monitoring treatment. For example, identification and monitoring of the BCR/ABL fusion gene in patients with chronic myelogenous leukemia or acute lymphocytic leukemia, for new diagnosis of APL using a probe for PML/RARA, and for detecting the cryptic t(12;21) in pediatric ALL. See also separate test listing for Cytogenetics, FISH Panel for CLL.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

FISH testing is performed as an adjunct to Chromosome Analysis when appropriate using the specimen submitted for Chromosome Analysis, unless otherwise approved by the Cytogenetics Laboratory Director. Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. See "Cytogenetics, Chromosome Analysis, Bone Marrow" or "Cytogenetics, Chromosome Analysis, Blood for Malignancy" for specimen collection and handling requirements.

Normal Volume
5 mL whole blood or 2 mL bone marrow
Minimum Volume
2 mL whole blood or bone marrow; additional specimen may be required for patients with extremely low white cell counts.

Billing Information

CPT Code
88237, 88271, 88275
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.