Fluorescence In Situ Hybridization (FISH)
Oncology probes are useful for assisting in diagnosis and classification of malignant hematologic disorders and certain solid tumors, evaluating prognosis and monitoring treatment. For example, identification and monitoring of the BCR/ABL fusion gene in patients with chronic myelogenous leukemia or acute lymphocytic leukemia, for new diagnosis of APL using a probe for PML/RARA, and for detecting the cryptic t(12;21) in pediatric ALL. See also separate test listing for Cytogenetics, FISH Panel for CLL.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
- ETV6/RUNX1 (TEL/AML1) t(12;21)
- FGFRI (8p11.2)
- BCR/ABL t(9;22)
- PML/RARA t(15;17)
- MLL t(11q23)
- IGH/CCND1 t(11;14)
- FISH Oncology Probes
- PDGFRB (5q32)
- RUNX1/RUNX1T1 t(8;21)
- CBFB/MYHII inv(16)
- CHIC2 deletion, FISH Probe
- PDGFRA/FIP1L1 (4q12)
- PDGFRA Translocation Detection by FISH
- GENERIC CYTOGENETICS TEST
- FISH for Neoplasia
FISH testing is performed as an adjunct to Chromosome Analysis when appropriate using the specimen submitted for Chromosome Analysis, unless otherwise approved by the Cytogenetics Laboratory Director. Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. See "Cytogenetics, Chromosome Analysis, Bone Marrow" or "Cytogenetics, Chromosome Analysis, Blood for Malignancy" for specimen collection and handling requirements.
The following FISH oncology probes are available: CBFB/MYHII inv(16), BCR/ABL t(9;22), IGH/CCND1 t(11;14), EVT/RUNX1 (TEL/AML1) t(12;21), PML/RARA t(15;17), RUNX1/RUNX1T1 T(8;21), MLL t(11q23), PDGFRA/FIP1L1 (4q12), PDGFRB (5q32), FGFR (8p11.2), del(13q). Additional probes may also be available; contact MLabs or the Cytogenetics laboratory for additional information. "Stand alone" FISH testing will include Tissue Culture at an additional charge.