Test Overview
Test Methodology

Cell culture and chromosome analysis. Fluorescence In Situ Hybridization (FISH) when indicated.

Test Usage

Evaluation of congenital malformations, still birth, mental retardation, growth retardation, infertility, cryptochidism, hypogonadism, amenorrhea (primary), abnormal or ambiguous genitalia, recurrent miscarriage, Turner syndrome, Klinefelter syndrome, Down syndrome, and other suspected chromosomal disorders.

Reference Range *

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Specimens older than 24 hours may not grow. If full thickness biopsy is not obtained, fibroblasts may not be plentiful enough to grow. Specimens collected using non-sterile techniques may have microbial contamination.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:00pm. Call the laboratory at 763-5805 for additional information.
Analytic Time

3 - 6 weeks

Soft Order Code
MiChart Code
Cytogenetics, Chromosome Analysis, Tissue for Genetic Disorder (Non-Maligna
  • Cytogenetics, Tissue
  • Chromosome Analysis, Skin Punch
  • Karyotype, Tissue
  • Chromosome Analysis, Tissue for Genetic Disorder (Non-malignant)
  • TCI
  • Chromosome Analysis, Skin Biopsy
Specimen Requirements
Collection Instructions

Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. Obtain skin biopsy. Use alcohol to cleanse skin; do not use betadine. If betadine must be used, wash betadine from skin with alcohol prior to biopsy. Place full-thickness biopsy in Chromosome Media, available from MLabs.

Rejection Criteria
Microbial contamination or specimens over 24 hours old.
Additional Information

Appropriate FISH testing will be performed at an additional charge when indicated. When chromosome analysis is requested to rule out certain conditions such as Turner syndrome (when indicated based on initial diagnosis) or suspected mosaicism, an additional cell count and/or special stains will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

CPT Code
88262 Chromosome Analysis, 88233 Tissue Culture
Fee Code
EA039 Chromosome Analysis, 36516 Tissue Culture