Test Overview
Test Methodology

Cell culture and chromosome analysis. Fluorescence In Situ Hybridization (FISH) when indicated.

Test Usage

Generally, products of conception are submitted for cytogenetic analysis if the couple has had 2 or more previous miscarriages, or if fetal abnormalities were observed. Approximately 50% of first trimester abortuses and 6% of later abortuses are chromosomally abnormal, frequently due to trisomy or monosomy following an abnormal meiotic division (nondisjunction). Chorionic villi (up to 12 weeks gestation) or fetal parts should be submitted for analysis; the Cytogenetics laboratory can isolate this material if an entire specimen or uterine contents is submitted un-fixed.

Reference Range *

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Specimens older than 24 hours may not grow. Specimens collected using non-sterile techniques may have microbial contamination.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time

3 weeks

Soft Order Code
CGNPC
MiChart Code
Cytogenetics, Chromosome Analysis/Karyotype, Products of Conception
Synonyms
  • CGLABEL
  • GENERIC CYTOGENETICS TEST
  • CGNPC
  • Cytogenetics, Fetal Tissue
  • Karyotype, Tissue
  • Chromosome Analysis, Placenta
  • Chromosome Analysis, Products of Conception (POC)
Laboratory
Cytogenetics
Section
Cytogenetics
Specimen Requirements
Collection Instructions

Store cytogenetic transport media frozen until ready for use. If possible, specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier or send via Priority Overnight delivery. Place POC specimen in a sterile screw top container containing cytogenetic transport media. If a kit is not available, use a sterile urine cup and sterile RPMI, sterile Hank’s Solution, or sterile saline for specimen transport. If using saline do not submerge the specimen, use just enough to keep it moist. Do not send the specimen dry. DO NOT ADD FORMALIN OR FREEZE. POCs often contain large numbers of bacteria so refrigerate if specimen must be stored overnight. Transport with a cold pack or at room temperature. Do not allow specimen to freeze. Submit the POC sample along with a completed MLabs Constitutional Cytogenetics Requisition form: http://mlabs.umich.edu/files/pdfs/REQ-Cytogenetics_REFR.pdf.

Rejection Criteria
Frozen specimens, specimens preserved in formalin, specimens consisting of only maternal tissue (decidua), specimens from a fetal demise over 48 hours, or grossly contaminated specimens are not acceptable.
Additional Information

This test includes a charge for cell culture of fresh specimens and interpretation of results. Analysis charges will be incurred for total work performed. If no metaphase cells are available for analysis, only a culture charge is assessed and no analysis charges will be incurred. Appropriate FISH testing or an additional cell count and/or special stains will be performed at an additional charge when indicated. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

Billing
CPT Code
88262 Chromosome Analysis, 88233 Tissue Culture
Fee Code
36543 Chromosome Analysis, 36545 Tissue Culture
Resources