Test Overview
Test Usage

Detection of in utero chromosome abnormalities.

Reference Range *

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time

10-14 days

Soft Order Code
MiChart Code
Cytogenetics, Chromosome Analysis/Karyotype, Chorionic Villi
  • Karyotype, Chorionic Villus Sampling
  • Karyotype, CVS
Specimen Requirements
Collection Instructions

Obtain 20 mg to 30 mg of chorionic villus specimen (CVS) by the transabdominal or transcervical method. Transfer the CVS to a Petri dish containing transport medium. Using a stereomicroscope and sterile forceps, assess the quality and quantity of the villi, and remove any blood clots and maternal decidua. Transfer the CVS by using sterile technique to one or two 15-mL centrifuge tube(s) with 15 mL of transport medium. Send specimen refrigerated. Specimen cannot be frozen.

Normal Volume
15-20 mg
Minimum Volume
5 mg
Rejection Criteria
No chorionic villus in specimen, gross contamination, formalin fixed or frozen specimens
Additional Information

For University of Michigan registered patients, when chromosome analysis is requested to rule out certain conditions such as Turner syndrome (when indicated based on initial diagnosis) or suspected mosaicism, an additional cell count and/or special stains will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

CPT Code
88267 Chromosome Analysis, 88235 Tissue Culture, 88285 Additional Cell Count
Fee Code
36554 Chromosome Analysis, 36544 Tissue Culture, 36552 Additional Cell Count