Particle Enhanced Immunoturbidimetric Assay (PENIA)
Cystatin C is produced by all nucleated cells at a constant rate and the production rate in humans appears to be constant over the entire lifetime. Elimination from the circulation is almost entirely via glomerular filtration. The serum concentration of Cystatin C is independent of muscle and gender in the age range of 1 to 50 years. It has been proposed that Cystatin C in serum or plasma is a more sensitive marker for GFR and superior to serum creatinine for estimation of GFR. Cystatin C may also be of value as a prognostic marker for acute heart failure.
2-18 years: 0.50 - 1.25 mg/L; 18-60 years: 0.60 - 1.15 mg/L; >60 years: 0.60 - 1.25 mg/L.
- Cystatin C
Collect specimen in a SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. Samples are acceptable for 7 days when stored refrigerated between 2 and 8C.