Test Overview

Test Methodology

Particle Enhanced Immunoturbidimetric Assay (PENIA)

Test Usage

Cystatin C is produced by all nucleated cells at a constant rate and the production rate in humans appears to be constant over the entire lifetime. Elimination from the circulation is almost entirely via glomerular filtration. The serum concentration of Cystatin C is independent of muscle and gender in the age range of 1 to 50 years. It has been proposed that Cystatin C in serum or plasma is a more sensitive marker for GFR and superior to serum creatinine for estimation of GFR. Cystatin C may also be of value as a prognostic marker for acute heart failure.

Reference Range*

2-18 years: 0.50 - 1.25 mg/L; 18-60 years: 0.60 - 1.15 mg/L; >60 years: 0.60 - 1.25 mg/L.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed


Analytic Time

2 hours.

Soft Order Code


MiChart Code

Cystatin C, Serum



Cystatin C

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Chemical Pathology

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. Samples are acceptable for 7 days when stored refrigerated between 2 and 8C.


Yellow Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.25 mL serum

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