5 - 7 days
Skin Antibodies (Pemphigus and Pemphigoid), Serum
Bullous lupus erythematosus
Linear IgA disease
Epidermolysis bullosa acquisita
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Detection of IgG anti-intercellular substance (ICS) and anti-basement membrane zone (BMZ) antibodies by indirect immunofluorescence technique using Rhesus monkey esophagus substrate and human NaCl split-skin substrate.
Confirming a diagnosis of pemphigoid, pemphigus, EBA, or bullous LE. Monitoring therapeutic response in patients with pemphigus.
Negative in normal individuals. Report includes presence and titer of circulating antibodies. If serum contains anti-basement membrane zone (BMZ) antibodies on split-skin substrate, patterns will be reported as: 1) epidermal pattern, consistent with pemphigoid or 2) dermal pattern, consistent with epidermolysis bullosa acquisita.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect blood in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial, and refrigerate. Include patient history on requisition. Indicate possible diagnosis on requisition: Pemphigus, Bullous Pemphigoid, Cicatricial Pemphigoid, Epidermolysis Bullosa Acquisita, Herpes gestationis, Linear IgA Disease, or Other.