Days Set Up
Monday - Friday
Analytic Time

5 - 7 days

MiChart Code
Cutaneous Immunofluorescence Antibodies, Serum (Sendout)
Soft Order Code

Test Updated:


Skin Antibodies (Pemphigus and Pemphigoid), Serum
Paraneoplastic pemphigus
Pemphigus vulgaris
Epidermal Antibodies
Bullous lupus erythematosus
Linear IgA disease
Cicatricial pemphigoid
Herpes gestationis
Epidermolysis bullosa acquisita
Bullous pemphigoid

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Test Overview

Test Methodology

Detection of IgG anti-intercellular substance (ICS) and anti-basement membrane zone (BMZ) antibodies by indirect immunofluorescence technique using Rhesus monkey esophagus substrate and human NaCl split-skin substrate.

Test Usage

Confirming a diagnosis of pemphigoid, pemphigus, EBA, or bullous LE. Monitoring therapeutic response in patients with pemphigus.

Reference Range

Negative in normal individuals. Report includes presence and titer of circulating antibodies. If serum contains anti-basement membrane zone (BMZ) antibodies on split-skin substrate, patterns will be reported as: 1) epidermal pattern, consistent with pemphigoid or 2) dermal pattern, consistent with epidermolysis bullosa acquisita.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect blood in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial, and refrigerate. Include patient history on requisition. Indicate possible diagnosis on requisition: Pemphigus, Bullous Pemphigoid, Cicatricial Pemphigoid, Epidermolysis Bullosa Acquisita, Herpes gestationis, Linear IgA Disease, or Other.

Yellow Top Tube
Normal Volume
2 mL serum
Minimum Volume
0.5 mL serum

Billing Information

CPT Code
88346, 88350
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.