Test Overview

Test Methodology

Capillary Electrophoresis

Test Usage

Serum protein electrophoresis is an evaluation for monoclonal gammopathies, Waldenstrom's macroglobulinemia, multiple myeloma, liver disease, inflammatory states, nephrotic syndrome, amyloidosis and A1At deficiency disease. Also used for evaluation of low back pain, arthritis, lymphoma, leukemia and anemia. The small bands and minor alterations detected will have different significance depending on the clinical situation.

Reference Range*

Total Protein (age >=12yrs): 6.0 - 8.3 g/dL; Albumin: 3.43 - 4.84 g/dL, Alpha-1 Globulin: 0.21 - 0.44 g/dL, Alpha-2 Globulin: 0.54 - 0.97 g/dL, Beta Globulin: 0.65 - 1.03 g/dL, Gamma Globulin: 0.70 - 1.47 g/dL, Albumin/Globulin Ratio: 0.88 - 2.30. Pathologist interpretation of results provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Monday - Friday

Analytic Time

24 hours

Soft Order Code


MiChart Code

Cryo Follow-up Protein Electro., Ser


Chemical Pathology

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Specimen Requirements

Offsite Collection Instructions

Whole blood must be maintained at 37 degrees C +/- 2 degrees from the time it is collected until serum is separated from the cells. Collect blood in pre-warmed red top tube (serum separator is unacceptable). Immediately place the specimen into a 37 degrees +/- 2 C incubator or water bath. Leave at 37 degrees C until the clot retracts, remove serum from clot, centrifuge at room temperature, and aliquot cell free serum into plastic aliquot tube. Please note on the specimen label that the specimen was processed at 37 degrees C. Keep serum at room temperature until delivered to MLabs. If specimen processing equipment is not available, the patient should have the specimen collected at a Michigan Medicine Taubman Center Blood Draw Station.

Special Handing

Place specimen in 37 degrees C Thermos containing a warm pack or waterbath immediately. See Collection Instructions below.

Rejection Criteria

Specimen not collected in red top tube (SST is not acceptable) and/or not stored and transported in a warm thermos.


Red Top Tube

Normal Volume

1 mL serum

Minimum Volume

0.5 mL serum

Additional Information

Test includes a pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation. In order to provide an accurate interpretation, abnormal results may be followed by serum immunoglobulins, serum immunofixation at an additional charge, and by immunoglobulin free light chains and/or immunoglobulin G subclass 4 at an additional charge, if clinically indicated. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

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