Test Overview
Test Methodology

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Test Usage

To accurately follow known cryoglobulin monoclonal gammopathy patients. To follow, identify and type monoclonal immunoglobulins for heavy and light chain specificity. Monoclonal gammopathy evaluation (MGE) is essential when clinical, hematologic, or pathologic findings indicate: multiple myeloma, Waldenstrom;s, heavy chain disease, amyloidosis, or immunoglobulin deposition disease. MGE is also essential in the presence of abnormal bands on serum protein electrophoresis (TPE), in cryoglobulins, in Bence Jones proteinuria, in pyroglobulins, and in hyperviscosity syndrome.
Test includes serum protein electrophoresis, total protein, immunoglobulin quantitation (IgG, IgA, IgM), and serum free light chains.

Reference Range *

Pathologist interpretation of results provided. See individual test reference ranges.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

72 hours

Soft Order Code
MiChart Code
Cryo Follow-up Monoclonal Gammopathy
Chemical Pathology
Specimen Requirements
Collection Instructions

Whole blood must be maintained at 37 degrees C +/- 2 degrees from the time it is collected until serum is separated from the cells. Collect blood in pre-warmed red top tube (serum separator is unacceptable). Immediately place the specimen into a 37 degrees +/- 2 C incubator or water bath. Leave at 37 degrees C until the clot retracts, remove serum from clot, centrifuge at room temperature, and aliquot cell free serum into plastic aliquot tube. Please note on the specimen label that the specimen was processed at 37 degrees C. Keep serum at room temperature until delivered to MLabs. If specimen processing equipment is not available, the patient should have the specimen collected at a Michigan Medicine Taubman Center Blood Draw Station.

Special Handling

Place specimen in 37 degrees C Thermos containing a warm pack or waterbath immediately. See Collection Instructions below.

Normal Volume
2 mL serum
Minimum Volume
1 mL serum
Storage Temperature
37 degrees C or room temperature after separation
Rejection Criteria
Specimen not collected in red top tube (SST is not acceptable) and/or not stored and transported in a warm thermos.
Additional Information

Test includes pathologist interpretation of results billed as a separate charge. This test is not available without interpretation. Test includes serum protein electrophoresis, total protein, immunoglobulin quantitation (IgG, IgA and IgM) and immunoglobulin free light chains.

CPT Code
84165, 82784 x3, 83883 x2
Fee Code
30951 TPECR, 21986 21987 219888 IGSCR, 33300 KFLC, 36100 LFLC
Pro Fee CPT
84165-26, TPE
Pro Fee Code
84165 TPE
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