Preliminary results are reported in 48 hours; final results are reported in 7 days.
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Incubation of serum at 4 degrees C and 37 degrees C, positive cryoglobulins redissolved and further characterized. Interpretation of positive results is made by a pathologist. Cryocrit run on positive cryoglobulins to determine what percent of the serum is cryoglobulin.
Cryoglobulin detection. Cryoglobulins may be present in multiple myeloma, Waldenstrom's macroglobulinemia, lymphocytic leukemia, autoimmune diseases and hepatitis C infection.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Whole blood must be maintained at 37 degrees C +/- 2 degrees C from the time it is collected until serum is separated from the cells. Collect blood into prewarmed red top tubes (serum separator tube is unacceptable). Within one minute, specimen must be placed into a 37 degrees C +/- 2 degrees C incubator or waterbath. Leave specimen at 37 degrees C until clot retracts; blood may be left at 37 degrees C up to 24 hours. After the clot retracts, remove serum from clot, centrifuge at room temperature, and aliquot 5 mL cell free serum into two aliquot tubes (2.5 mL each). Please note on requisition or as a footnote in the computer that the specimen was processed at 37 degrees C. Keep serum specimen at ambient (room) temperature until delivered to MLabs. If specimen processing equipment is not available, the patient should have the specimen collected at a University of Michigan Taubman Center Blood Drawing station.