Quantitation and Qualitative Typing Precipitation at 1 Degree C.
Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases and evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure.
CRYOGLOBULIN: Negative (positives reported as a percent). CRYOFIBRINOGEN: Negative. Quantitation and immunotyping will not be performed on positive cryofibrinogen. An interpretive report will be provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Days Test Performed
Monday - Friday
2 - 10 days
Soft Order Code
Cryoglobulin and Cryofibrinogen Panel **Onsite drawstations only - Do Not D
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Offsite Collection Instructions
Specimens must be maintained at 37 degrees C +/- 2 degrees C from the time they are collected until plasma or serum is separated from the cells.
LAVENDER TOP: Collect specimen in a lavender top tube (plasma gel tube is unacceptable). Blood may be centrifuged immediately in a room temperature centrifuge. If this is not possible, the specimens can be placed in a 37 degrees C waterbath until they can be centrifuged. Specimen should be centrifuged at 37 degrees; ambient is acceptable if 37 degrees is not plausible. Aliquot plasma into a plastic vial. After the plasma is removed, place in the refrigerator; please note on the requisition or as a footnote in the computer that the specimen was processed at 37 degrees C.
RED TOP: Collect specimen in a red top tube (serum separator tube is unacceptable). Within one minute, specimen must be placed into a 37 degrees C +/- 2 degrees C incubator or waterbath. Leave specimen at 37 degrees C until specimen is clotted. Specimen should be centrifuged at 37 degrees; ambient is acceptable if 37 degrees is not plausible. Aliquot serum into a plastic vial. After the serum is removed, place in the refrigerator; please note on the requisition or as a footnote in the computer that the specimen was processed at 37 degrees C.
If the necessary specimen processing equipment is not available, the patient should have the specimen collected at a University of Michigan Taubman Center Blood Drawing station.
Both plasma and serum are required. Specimens must be maintained at 37 degrees C +/- 2 degrees C from the time they are collected until plasma or serum is separated from the cells. Place specimens in a 37 degrees C Thermos containing a warm pack or waterbath immediately. See Collection Instructions below.
SST or PST tube not acceptable.
This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.
3 mL EDTA plasma AND 5 mL serum (15 mL whole blood in a red top tube)
0.5 mL EDTA plasma AND 3 mL serum (10 mL whole blood in a red top tube)
Test includes cryoglobulin and cryofibrinogen. If cryoglobulin has a result other than negative, then immunofixation (IMFXC) will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Positive cryoglobulins of > or =0.1 mL of precipitate will be typed once. Test sent to Mayo Medical Laboratories.