Test Overview

Test Methodology

Colorimetic Rate

Test Usage

Evaluation of renal function

Reference Range*

1-4 years: 0.2 - 0.6 mg/dL, 5-11 years: 0.4 - 0.9 mg/dL, 12-150 years, male: 0.7 - 1.3 mg/dL, female: 0.5 - 1.0 mg/dL. Estimated Glomerular Filtration Rates (eGFR) for both an African American and a non-African American individual calculated using the MDRD study equation will be reported with serum creatinine levels ordered alone or as part of a panel for patients aged 18 - 100 years. A GFR estimate between 15 and 59 mL/min for >= 3 months is classified as chronic kidney disease (Stage 3 or 4).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

The MDRD formula for estimation of GFR (eGFR) was developed in a population of adults with slowly-declining or stable reduced kidney function. The MDRD formula should not be used to predict eGFR in unstable patients or in children. The GFR estimate can be interpreted accurately only during a steady state of creatinine balance. The GFR estimate will overestimate true GFR if serum creatinine is rising (such as in acute kidney failure) and will underestimate true GFR if serum creatinine is declining (such as in resolution of acute kidney failure). The EGFR should not be used for pharmacy drug dosing.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

2 hours

Soft Order Code


MiChart Code




GFR (Glomerular Filtration Rate)
Glomerular Filtration Rate (GFR)

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Chemical Pathology

STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.


Yellow Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.25 mL serum

Additional Information

The Jaffe reaction used for creatinine on the Advia 2400 can exhibit a positive bias or interference with a number of different compounds. The most common are high levels of ascorbic acid and certain cephalosporin antibiotics (Cefpirone, Cefoxitin, Cefazolin, and Cephalothin). Patients may exhibit fairly dramatic changes in serum creatinine (0.5 - 1.0 mg/dL increases) if samples happen to be drawn at peak drug levels.

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CPT Code




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