Test Overview

Test Methodology

Colorimetric Rate

Test Usage

Evaluation and monitoring of disorders of skeletal and cardiac muscle. Creatine Kinase only is performed. Order CK, Total and MB Isoenzymes (TCK) if reflex testing is desired for CKMB.

Reference Range*

Male: 38 - 240 IU/L; Female: 26 - 180 IU/L

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

2 hours

Soft Order Code


MiChart Code

CK (Creatine Kinase)



CK Total
Creatine Phosphokinase

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Chemical Pathology

STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a green top tube. Centrifuge, aliquot plasma into a plastic vial and refrigerate.

Normal Volume

0.5 mL plasma

Minimum Volume

0.25 mL plasma

Additional Information

Creatine Kinase (CK) is localized primarily in skeletal muscle, cardiac muscle, and the brain. Serum CK is elevated in all types of muscular dystrophy, viral myositis, polymyositis, and in any disorder where there is destruction of muscle tissue. Following myocardial infarction, total CK activity starts to rise within 4-8 hrs, peaks at 18-30 hrs, and returns to normal levels after 48-60 hrs. With thrombolytic therapy, CK activity rises earlier and faster and returns toward normal levels earlier than noted above.

Billing Information

Fee Codes

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