Test Overview
Test Methodology

LC-MS/MS.

Test Usage

Very helpful in evaluating suspected Cushing's syndrome. This test is specific for uncovering elevated urinary unconjugated cortisol. Low values may suggest adrenal insufficiency.

Reference Range *

CORTISOL: 0-2 years: not established, 3-8 years: 1.4 - 20.0 mcg/24hours, 9-12 years: 2.6 - 37.0 mcg/24 hours, 13-17 years: 4.0 - 56.0 mcg/24 hours, 18-150 years: 3.5 - 45.0 mcg/24 hours.
CORTISONE: 0-2 years: not established, 3-8 years: 5.5 - 41.0 mcg/24hours, 9-12 years: 9.9 - 73.0 mcg/24 hours, 13-17 years: 15 - 108 mcg/24 hours, 18-150 years: 17 - 129 mcg/24 hours.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Thursday
Analytic Time

2 days

Soft Order Code
CORTU
MiChart Code
Cortisol/Cortisone, Free, Urine
Synonyms
  • URINE FREE CORTISOL RESULT
  • Cortisol, Free
  • Free Cortisol
  • UFC
  • Urinary Free Cortisol
  • Urine Cortisol
  • URINE FREE CORTISOL
  • FCU
  • UCORT
Laboratory
Sendout
Reference Laboratory
Mayo CORTU
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect 24 hour urine specimen with no preservative. Aliquot 5 ml into a plastic tube and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Treatment with hydrocortisol should be discontinued at least 2 days prior to this test.

Rejection Criteria
Unrefrigerated urine, patient taking hydrocortisone, urine samples collected in HCl, Na2CO3 or 6N HNO3.
Normal Volume
5 ml aliquot of 24 hour urine collection
Minimum Volume
3 ml aliquot of 24 hour urine collection
Additional Information

Urinary cortisol reflects the portion of serum free cortisol filtered by the kidney. It correlates with cortisol secretion rates. Because the concentration of free cortisol in urine increases in adrenocortical hyper-function (i.e., Cushing's syndrome) but not in 'simple' obesity, measurement may be valuable in their differential diagnosis.

Billing
CPT Code
82530
Fee Code
AA429
LOINC
2147-7 (Urine Free Cortisol mcg/24 hours)
NY State Approved
No
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