Days Set Up
Monday, Thursday
Analytic Time

24 hours

MiChart Code
Cold Agglutinin Screen
Soft Order Code

Test Updated:


Agglutinins, Cold

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology


Test Usage

Support the diagnosis of primary atypical pneumonia (Mycoplasma pneumoniae), hemolytic anemia, cirrhosis, Raynaud's disease, some viral diseases, and infectious diseases such as staphylococcemia and influenza. May also occur in pregnancy. A fourfold rising and falling titer is found in primary atypical pneumonia (PAP); 55% of patients with PAP have rising titers. Ninety percent of these are severely affected or have prolonged illness.

Reference Range

Titer less than 1:40

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a red top tube; do not use SST tube. Maintain specimen at room temperature. In the laboratory, process as follows: 1) Place specimen in 37 degrees C waterbath or incubator for 30 minutes and allow to clot. 2) After 30 minute incubation at 37 degrees C, centrifuge specimen at 2000 rpm for 5 minutes. 3) Aliquot serum into a plastic vial and refrigerate. 4) Indicate on requisition or manifest that the specimen was incubated at 37 degrees C for 30 minutes. If specimen processing equipment is not available, the patient should have the specimen collected at an Mlabs Blood Drawing station.

Red Top Tube
Normal Volume
7 mL whole blood
Minimum Volume
3 mL whole blood

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.