Photo-optical clot determination with Factor II deficient substrate.
Detection of specific coagulation factor II deficiency
Increased in patients taking oral contraceptives. Interpretation of results may be limited if patient is receiving anticoagulant therapy.
- Factor II Assay
- Factor II:C Assay
- Factor 2 Assay
- Factor 2 Activity
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.
Factor II is decreased with vitamin K deficiency, liver disease, during warfarin therapy, and in association with lupus anticoagulant.