Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Therapeutic Drug Monitoring
Clozapine: >350 ng/mL; Clozapine & Norclozapine: >450 ng/mL.
3 - 5 days
- Clozapine, Plasma/Serum
Clozapine is an antipsychotic agent. Peak clozapine concentrations are reached in 1-6 hours following oral dosage. Elimination half-life is 4-16 hours once steady state levels have been reached. Norclozapine has minimal therapeutic activity. Test sent to Mayo Medical Laboratories; performed by Mayo New England.