Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Therapeutic Drug Monitoring
Clonazepam Anticonvulsant: 20 – 70 ng/mL; Anxiolytic: 4 – 80 ng/mL. Some individuals may show therapeutic response outside of these ranges, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. Note: Therapeutic ranges are for specimens drawn at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.
4 - 8 days
- Clonazepam, Serum
Collect specimen in a red top tube; do not use SST tube. Centrifuge within 2 hours, aliquot serum into a plastic vial and refrigerate.
Specimen must be spun and aliquotted within 2 hours of collection
Test performed by Mayo Clinic Laboratories.