Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Monitor therapeutic drug levels; monitor patient compliance; evaluate clomipramine toxicity.
Therapeutic: 70 - 200 ng/mL; Toxic: > 500 ng/mL (sum of Clomipramine and Norclomipramine).
Phenothiazines and other tricyclic antidepressants may interfere when administered concomitantly.
- CLOMIPRAMINE RESULT
- CLOMIPRAMINE LEVEL
- NORCLOMIPRAMINE LEVEL
- Tricyclics, Clomipramine and Norclomipramine
Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.
Norclomipramine, the active metabolite of clomipramine, is also measured.