Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate clomipramine toxicity.

Reference Range *

Therapeutic: 70 - 200 ng/mL; Toxic: > 500 ng/mL (sum of Clomipramine and Norclomipramine).

Test Limitations

Phenothiazines and other tricyclic antidepressants may interfere when administered concomitantly.

Test Details
Days Set Up
Tuesday
Analytic Time

4 hours

Soft Order Code
CLOM
MiChart Code
Clomipramine and Norclomipramine
Synonyms
  • CLOMIPRAMINE RESULT
  • CLOMIPRAMINE LEVEL
  • NORCLOMIPRAMINE LEVEL
  • Anafranil
  • Tricyclics, Clomipramine and Norclomipramine
  • CLOMIPRAMINE
  • CLOMIP
  • NORCLOM
  • NORCLOMIPRAMINE
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.

Yellow Top Tube
Red Top Tube
Alternate Specimen
Laveder top (EDTA plasma) [11/09]
Rejection Criteria
SST or PST tube not acceptable.
Normal Volume
1 mL serum or plasma
Minimum Volume
0.7 mL serum or plasma
Additional Information

Norclomipramine, the active metabolite of clomipramine, is also measured.

Billing
CPT Code
80335
Fee Code
20014
LOINC
Z51-3
NY State Approved
No