Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate clomipramine toxicity.

Reference Range *

Therapeutic: 230 - 450 ng/mL (sum of Clomipramine and Norclomipramine). Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Tuesday, Thursday, Sunday
Analytic Time

3 - 5 days

Soft Order Code
MCLOM
MiChart Code
Clomipramine and Norclomipramine
Synonyms
  • Anafranil
  • Tricyclics, Clomipramine and Norclomipramine
Laboratory
Sendout
Reference Laboratory
Mayo CLOM
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a red top tube immediately before next scheduled dose (minimum 12 hours after last dose); do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial within 2 hours of collection, and refrigerate.

Normal Volume
1 mL serum
Minimum Volume
0.25 mL serum
Rejection Criteria
SST or PST tube not acceptable.
Additional Information

Norclomipramine, the active metabolite of clomipramine, is also measured. Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
80335
Fee Code
AB141
LOINC
43127-0
NY State Approved
No