Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate clomipramine toxicity.

Reference Range *

Therapeutic: 70 - 200 ng/mL; Toxic: > 500 ng/mL (sum of Clomipramine and Norclomipramine).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Phenothiazines and other tricyclic antidepressants may interfere when administered concomitantly.

Test Details
Days Set Up
Thursday
Analytic Time

4 hours

Soft Order Code
CLOM
MiChart Code
Clomipramine and Norclomipramine
Synonyms
  • CLOMIPRAMINE RESULT
  • CLOMIPRAMINE LEVEL
  • NORCLOMIPRAMINE LEVEL
  • Anafranil
  • Tricyclics, Clomipramine and Norclomipramine
  • CLOMIPRAMINE
  • CLOMIP
  • NORCLOM
  • NORCLOMIPRAMINE
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.

Alternate Specimen
Laveder top (EDTA plasma) [11/09]
Rejection Criteria
SST or PST tube not acceptable.
Yellow Top Tube
Red Top Tube
Normal Volume
1 mL serum or plasma
Minimum Volume
0.7 mL serum or plasma
Additional Information

Norclomipramine, the active metabolite of clomipramine, is also measured.

Billing
CPT Code
80335
Fee Code
20014
LOINC
Z51-3
Resources