Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the CIC gene region (19q13) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using break-apart probes to qualitatively assess for the presence of CIC translocations that occur in up to two-thirds of undifferentiated small round cell sarcomas that are negative for EWSR1 rearrangement.
Interpretive report provided.
This test will detect rearrangements involving CIC but will not identify the translocation partner.
3 - 10 days
- Undifferentiated Small Round Cell Sarcoma
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.