3 - 10 days
Undifferentiated Small Round Cell Sarcoma
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Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the CIC gene region (19q13) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using break-apart probes to qualitatively assess for the presence of CIC translocations that occur in up to two-thirds of undifferentiated small round cell sarcomas that are negative for EWSR1 rearrangement.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.