Test Overview
Test Methodology

Chromosomal Microarray

Reference Range *

Interpretive report provided

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

This test does not detect all types and instances of uniparental disomy. This test is not designed to detect low-level mosaicism, although it can be detected in some cases. This test does not detect point alterations, small deletions or insertions below the resolution of this assay, or other types of variants such as epigenetic changes. The results of this test may reveal incidental findings not related to the original reason for referral. In such cases, studies of additional family members may be required to help interpret the results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

10-21 days

Soft Order Code
  • CMA
Reference Laboratory
Special Testing
Specimen Requirements
Collection Instructions

Amniotic fluid:
1. Optimal timing for specimen collection is during 14 to 18 weeks of gestation, but specimens collected at other weeks of gestation are also accepted. Provide gestational age at the time of amniocentesis.
2. Discard the first 2 mL of amniotic fluid.
3. Send the specimen and CMA patient history form to Specimen Processing
1. Collect specimen by the transabdominal or transcervical method.
2. Transfer chorionic villi to a Petri dish containing transport medium (Such as CVS Media [RPMI] and Small Dish).
3. Using a stereomicroscope and sterile forceps, assess the quality and quantity of the villi and remove any blood clots and maternal decidua. Transfer to a screw capped transport tube and send to Specimen Processing along with the CMA patient history form.

A maternal blood sample is requested (separate order for Mayo test PPAP) and should be sent along with the Amniotic fluid/CVS

Special Handling

1. Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
2. Notify the laboratory if the pregnancy involves an egg donor or gestational carrier.

Normal Volume
20-30 mL amniotic fluid; 20-30 mg of CVS in 15 mL of RPMI
Minimum Volume
12 mL Amniotic fluid; 12 mg of CVS
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability
Additional Information

Test performed by Mayo Clinic Laboratories

CPT Code