Test Overview
Test Methodology

Chromosomal Microarray

Test Usage

Diagnosis of congenital copy number changes in products of conception, including aneuploidy (ie, trisomy or monosomy) and structural abnormalities. Diagnosing chromosomal causes for fetal death
Determining recurrence risk of future pregnancy losses. Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected previously by other methods such as conventional chromosome and fluorescence in situ hybridization (FISH) studies
Determining if apparently balanced abnormalities identified by previous conventional chromosome studies have cryptic imbalances, since a proportion of such rearrangements that appear balanced at the resolution of a chromosome study are actually unbalanced when analyzed by higher-resolution chromosomal microarray

Reference Range *

Interpretive report provided

Test Details
Days Set Up
Monday - Friday
Analytic Time

21 - 30 days

Soft Order Code
CMAMT
Laboratory
Sendout
Reference Laboratory
Mayo CMAMT
Section
Special Testing
Specimen Requirements
Collection Instructions

A reason for referral and pathology report are required in order for testing to be performed. Send information with specimen. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports. Send the report along with the block OR slides

Normal Volume
Entire block, or 6 consecutive, unstained, 5-micron thick sections placed on positively charged slides and 1 H&E stained slide
Minimum Volume
Entire block OR 5 unstained and 1 H&E stained slides
Storage Temperature
Ambient preferred, refrigerated acceptable
Rejection Criteria
If a fresh tissue specimen is submitted, this test will be cancelled and CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillborn, Varies will be added and performed as the appropriate test.
Additional Information

Test performed by Mayo Clinic Laboratories

Billing
CPT Code
81229
NY State Approved
No