Test Overview
Test Methodology

Chromosomal Microarray

Test Usage

Prenatal diagnosis of copy number changes (gains or losses) across the entire genome. Diagnosing chromosomal causes for fetal death. Determining recurrence risk of future pregnancy losses.
Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected by other methods such as conventional chromosome and fluorescence in situ hybridization (FISH) studies. Determining if apparently balanced abnormalities identified by previous conventional chromosome studies have cryptic imbalances, since a proportion of such rearrangements that appear balanced at the resolution of a chromosome study are actually unbalanced when analyzed by higher-resolution chromosomal microarray. Assessing regions of homozygosity related to uniparental disomy or identical by descent

Reference Range *

Interpretive report provided

Test Details
Days Set Up
Monday - Friday
Analytic Time

21 - 30 days

Soft Order Code
CMAPC
Laboratory
Sendout
Reference Laboratory
Mayo CMAPC
Section
Special Testing
Specimen Requirements
Collection

Additional instructions for muscle biopsy, if sending:
1. Wash biopsy site with an antiseptic soap.
2. Thoroughly rinse area with sterile water.
3. Do not use alcohol or iodine preparations.
4. Biopsy specimens are best taken by punch biopsy to include full thickness of dermis.

Collection Instructions

1. Attempt to identify and send only fetal tissue for analysis.
2. If a fetus cannot be specifically identified, collect 50-mg villus material or tissue that appears to be of fetal origin.
3. If multiple specimen types are sent, send each specimen in a separate container. Multiple specimens received (eg, placenta and fetal thigh) will be ordered under 1 test. All specimens will be processed separately
Send the container(s) to Specimen Processing ambient

Special Handling

1. Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
2. Notify the laboratory if the pregnancy involves an egg donor or gestational carrier.

Normal Volume
POC or stillborn: 1 cm(3) of placenta AND 1 cm(3) biopsy specimen of muscle/fascia from thigh. (Do not send the entire fetus)
Autopsy: 1 cm(3) biopsy specimen of muscle/fascia from thigh
Storage Temperature
Ambient preferred, refrigerated acceptable
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Additional Information

Test performed by Mayo Clinic Laboratories

Billing
CPT Code
81229
NY State Approved
No