Test Overview
Molecular Typing (SSOP)
The HLA class II antigens DQ2 (DQA1*05/DQB1*02) and DQ8 (DQA1*0301/DQB1*0302) are the major risk factors predisposing individuals to Celiac Disease and account for over 35% of the genetic risk. Close to 90% of patients with Celiac Disease express the HLA-DQ2 molecules with most of the remainder expressing the HLA-DQ8 molecule. The DQ variant DQA1*02/DQB1*02 is associated with weak/equivocal risk of Celiac Disease.
Interpretive report will indicate presence or absence of HLA-DQ2 and DQ8.
Test Details
5 days
- Celiac Disease - HLA DQ2 or DQ8
- DQ2 Antigen
- DQ8 Antigen
- HLA DQ2
- HLA DQ8
- TTYPE
- TISSUE TYPING
- HLA REPORT
- CELI
- Celiac Disease, HLA
- HLA Class II One Locus (Low Resolution)
- Celiac Disease Genetic Assessment
Specimen Requirements
Collect specimen in sufficient yellow top (ACD) solution A tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.
Additional Information
Celiac disease is a type of chronic inflammatory disease. It is characterized by diarrhea, abdominal distension, poor weight gain and short stature. The diseases have multifactorial etiologies that involve environmental components and genetic factors including HLA genes. Celiac disease patients exposed to a gluten-containing diet develop antibodies specific to various antigens, including gluten and the autoantigen tissue transglutaminase (TG2). Celiac disease is a lifelong condition, with the only effective treatment being complete exclusion of gluten from diet.