Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug level.

Reference Range *

CEPOX: Therapeutic Toxic/Critical
0.4 - 4.0 ug/mL N/A
CBZN:
(single regimen) 8.0 - 12.0 ug/mL >15.0 ug/mL
(multiple regimen) 4.0 - 8.0 ug/mL N/A

The concentration of carbamazepine epoxide is normally 10-40% that of the parent drug, but can be variable. During combination therapy the relative concentration of carbamazepine epoxide to carbamazepine may increase slightly.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

48 hours

Soft Order Code
CEPOX
MiChart Code
Carbamazepine Epoxide
Synonyms
  • Carbamazepine 10,11-epoxide
  • Tegretol
  • Tegretol Epoxide
Laboratory
Clinical Core Laboratory
Section
Toxicology & Specialized Mass Spectrometry
Specimen Requirements
Collection Instructions

Collect blood in a red top tube; do not use SST. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Alternate Specimen

Heparinized (green top) or EDTA (lavender top) plasma acceptable.

Normal Volume

2 mL serum

Minimum Volume

0.3 mL serum

Rejection Criteria
SST tube not acceptable.
Billing
CPT Code
80161
Fee Code
KA036
LOINC
9415-1
NY State Approved
No