Test Overview

Test Methodology

Crossed Immunoelectrophoresis

Test Usage

Useful in distinguishing between the types of membranoproliferative glomerulonephritis and for monitoring treatment.

Reference Range*

0.00 - 0.30

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Tuesday

Analytic Time

14 - 16 days

Soft Order Code

MMLR

Synonyms

Synonyms

C3NeF
Complement C3 Nephritic Factor

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Laboratory

Sendout

Laboratory Reference

Mayo Wild 85 (ZW85) (National Jewish Health)

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial and freeze within 2 hours of collection.

Rejection Criteria

SST tube not acceptable.

Container

Yellow Top Tube
Red Top Tube

Normal Volume

1 mL serum

Minimum Volume

0.25 mL serum

Additional Information

C3 NeF is an autoantibody that binds to the alternative pathway C3 convertase and prolongs its activity in vivo. Its presence can be detected by mixing the patient's serum with normal serum and looking for conversion of the C3 in the normal serum by 2-dimensional immunoelectrophoresis under conditions that only allow alternative pathway activation. This assay measures C3 NeF function and is semi-quantitative. Test sent to Mayo Medical Laboratories; performed by National Jewish Health.

Billing Information

Fee Codes


CPT Code

86161

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