Useful in distinguishing between the types of membranoproliferative glomerulonephritis and for monitoring treatment.
0.00 - 0.30
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Days Test Performed
14 - 16 days
Soft Order Code
Complement C3 Nephritic Factor
Mayo Wild 85 (ZW85) (National Jewish Health)
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Offsite Collection Instructions
Collect specimen in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial and freeze within 2 hours of collection.
SST tube not acceptable.
1 mL serum
0.25 mL serum
C3 NeF is an autoantibody that binds to the alternative pathway C3 convertase and prolongs its activity in vivo. Its presence can be detected by mixing the patient's serum with normal serum and looking for conversion of the C3 in the normal serum by 2-dimensional immunoelectrophoresis under conditions that only allow alternative pathway activation. This assay measures C3 NeF function and is semi-quantitative. Test sent to Mayo Medical Laboratories; performed by National Jewish Health.