Inductively coupled Plasma/Mass Spectrometry (ICP/MS)
Assessing possible toxicity. Bromides are ingested principally in sedatives.
The general range of normal levels is 0.3 - 1.2 mg/dL with an average of approximately 0.5 mg/dL. Background concentrations are diet dependent. Workers exposed to methyl bromide with blood bromide concentrations greater than 1.2 mg/dL have shown 3.5 times higher risk of electroencephalogram disturbances than compared to those with normal levels. The bromide concentration may be elevated beyond normal levels if the individual is using bromides therapeutically. The antiepileptic effects of bromides are generally associated with plasma levels ranging from 75 - 150 mg/dL. The ratio of blood to plasma concentrations is 0.7 – 0.8.
10 - 12 days
- Bromide, Serum
- BROMIDE, BLOOD
Collect specimen in a Royal blue trace element tube with EDTA tube. Refrigerate and send intact whole blood specimen.
Bromides are used outside the United States to treat grand mal and focal epilepsy. Signs of acute toxicity include nausea, vomitting, and diarrhea. Manifestations of chronic toxicity can include lethargy, fatigue, irritability, loss of appetite, tachypnea, skin pigmentation, hallucinations, ataxia, and coma. Test sent to Mayo Medical Laboratories; performed by NMS Labs.