Days Set Up
Monday, Wednesday, Thursday
Analytic Time

1 day

MiChart Code
Lyme Disease Serology Spinal Fluid (Sendout)
Soft Order Code

Test Updated:


Borrelia burgdorfei Antibody, Spinal Fluid
Lyme Disease Antibody, CSF
Tick Borne Disease

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Test Usage

Aid in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to infection with Lyme disease associated Borrelia species (eg, B. burgdorferi, B. garinii, B. afzelli). The Lyme Antibody Index assay is designed to differentiate between true intrathecal synthesis of antibodies to Borrelia burgdorferi sensu lato (Bbsl) genospecies (e.g., B. burgdorferi, B. garinii and B. afzelii) versus the presence of anti-Bbsl antibodies in CSF due to permeability of the blood-brain barrier or as a result of a traumatic lumbar puncture.

Reference Range


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect CSF specimen in sterile tube or container. Send CSF specimen refrigerated (preferred) or frozen in a screw-capped plastic vial. Label as spinal fluid or CSF. Collect blood specimen in an SST tube within 24 hours of the CSF specimen, preferably at the same time. Centrifuge, aliquot serum into a plastic vial and refrigerate (preferred) or freeze. Label as serum. Band CSF and serum specimens together.

Yellow Top Tube
Normal Volume
1.5 mL CSF AND 1.5 mL serum
Minimum Volume
1.2 mL CSF AND 1.2 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.