Test Overview
Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Test Usage

Aid in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to infection with Lyme disease associated Borrelia species (eg, B. burgdorferi, B. garinii, B. afzelli). The Lyme Antibody Index assay is designed to differentiate between true intrathecal synthesis of antibodies to Borrelia burgdorferi sensu lato (Bbsl) genospecies (e.g., B. burgdorferi, B. garinii and B. afzelii) versus the presence of anti-Bbsl antibodies in CSF due to permeability of the blood-brain barrier or as a result of a traumatic lumbar puncture.

Reference Range *

Negative

Test Details
Days Set Up
Monday, Wednesday, Thursday
Analytic Time

1 day

Soft Order Code
LNBAB
MiChart Code
Lyme Disease Serology Spinal Fluid (Sendout)
Synonyms
  • Borrelia burgdorfei Antibody, Spinal Fluid
  • BORRC
  • BORRELIA ANTIBODY, CSF (LYME)
  • Lyme Disease Antibody, CSF
  • LYMEC
  • Tick Borne Disease
Laboratory
Sendout
Reference Laboratory
Mayo LNBAB
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect CSF specimen in sterile tube or container. Send CSF specimen refrigerated (preferred) or frozen in a screw-capped plastic vial. Label as spinal fluid or CSF. Collect blood specimen in an SST tube within 24 hours of the CSF specimen, preferably at the same time. Centrifuge, aliquot serum into a plastic vial and refrigerate (preferred) or freeze. Label as serum. Band CSF and serum specimens together.

Yellow Top Tube
Normal Volume
1.5 mL CSF AND 1.5 mL serum
Minimum Volume
1.2 mL CSF AND 1.2 mL serum
Additional Information

Test sent to Mayo Medical Laboratories. If the Borrelia (Lyme Disease) CNS Infection IgG assay is reactive, the Antibody Index will be performed at an additional charge (Mayo LNBAI). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

Billing
CPT Code
86618
Fee Code
AA085
NY State Approved
No