Test Overview
Test Methodology

Colorimetric

Test Usage

Diagnosis of biotinidase deficiency.

Reference Range *

4.21-8.98 nmol/min/ml

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

A diet high in biotin may cause a patient to present a normal clinical presentation even though the biotinidase level is low. A low biotinidase should always be confirmed with a second sample. Sulfa drugs may interfere with this assay.

Test Details
Days Set Up
Varies; test set up once per week.
Analytic Time

5 - 10 days; contact MLabs Client Services Center or Pediatric Geneticist on Call if assay is needed on an urgent basis.

Soft Order Code
BI
MiChart Code
Biotinidase Level
Synonyms
    Laboratory
    MMGL
    Section
    MMGL Biochemical Genetics
    STAT Availability

    STAT analysis must be approved by Pediatric Geneticist on Call.

    Specimen Requirements
    Collection Instructions

    Collect specimen in a green top tube. Centrifuge, aliquot plasma into a plastic vial, and freeze within 4 hours of collection.

    Normal Volume
    2 mL plasma
    Minimum Volume
    1 mL plasma
    Storage Temperature
    (F)-frozen plasma
    Rejection Criteria
    Gross hemolysis or icterus.
    Additional Information

    Test may include medical geneticist interpretation of results at an additional charge. By ordering this test, the clinician acknowledges that a physician interpretation will be performed and billed as a separate additional charge if indicated.

    Billing
    CPT Code
    82261
    Fee Code
    23808
    NY State Approved
    No