Update Type: Specimen collection or handling and/or storage changed
Test Updated: 10/01/2025
Test Overview
Test Methodology

Nephelometry

Test Usage

Detection of cerebrospinal fluid (CSF) in other body fluids, such as nasal or ear fluid.

Reference Range *

Beta-trace protein concentration <5 mg/L is negative for cerebrospinal fluid
Beta-trace protein concentration 5-7 mg/L is indeterminate for presence of cerebrospinal fluid
Beta-trace protein concentration >7 mg/L is consistent with the presence of cerebrospinal fluid

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

1 - 3 days

Soft Order Code
BTP
MiChart Code
Beta-Trace Protein , Body Fluid
Synonyms
  • CSF in other body fluids
  • Otorrhea (ear fluid leak)
  • Rhinorrhea (nasal fluid leak)
Laboratory
Sendout
Reference Laboratory
Mayo BTP
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect nasal or other body fluid specimen in clean tube or container. Indicate specimen source, and include whether the source is from the right or left side of the body, if applicable. If direct collection is not feasible, specimen may be collected using a plain cotton swab or gauze. If gauze is used to collect specimen, circle area on the gauze where specimen was collected and place cotton swab or gauze in as small a container as possible (eg, plain test tube or collection container); do not collect specimen with a culture swab; do not add any liquid to the swab or gauze.

Normal Volume

0.5 mL fluid

Storage Temperature
Refrige preferred, ambient or frozen acceptable
Rejection Criteria
Specimens collected with additives such as microbiology media (eg, Stuart or Amies liquid medium) or TransFix/EDTA (used for analyses in flow cytometry) yield uninterpretable results and will be rejected.
Additional Information

Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
83883
Fee Code
AB204
LOINC
57733-8
NY State Approved
No