Test Overview
Test Methodology

Nephelometry

Test Usage

Beta-2-microglobulin (beta-2-m) is expressed on the surface of nucleated cells as a subunit of class I major histocompatibility complex molecules. Uncomplexed beta-2-m (11,800 daltons) is normally shed into the circulation in low concentration, freely filtered across glomerular basement membrane, and largely reabsorbed by proximal tubular epithelium. Increased serum/plasma concentrations of beta-2-m are frequently seen under conditions of increased cell turn over - including malignant neoplasms (especially B lymphocytes), inflammation, and some infections. Older studies of patients with multiple myeloma, before treatment, correlated high concentrations of beta-2-m with worse prognosis than observed in patients with myeloma and lower concentrations of beta-2-m. Elevated serum/plasma beta-2-m can be seen with decreased glomerular filtration rate/renal insufficiency. Elevated urine beta-2-m can be seen as a result of impaired proximal tubular reabsorption.

Reference Range *

0 - 2 mg/L

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

8 hours

Soft Order Code
B2MIC
MiChart Code
Beta 2 Microglobulin
Synonyms
  • B2MIC
  • B2 MICROGLOBULIN
Laboratory
Chemical Pathology
Section
Immunopathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Alternate Specimen
Red top tube
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum
Billing
CPT Code
82232
Fee Code
23373
LOINC
1952-1
Resources