Test Overview
Test Methodology

Turbidmetric

Test Usage

Beta-2-microglobulin (beta-2-m) is expressed on the surface of nucleated cells as a subunit of class I major histocompatibility complex molecules. Uncomplexed beta-2-m (11,800 daltons) is normally shed into the circulation in low concentration, freely filtered across glomerular basement membrane, and largely reabsorbed by proximal tubular epithelium. Increased serum/plasma concentrations of beta-2-m are frequently seen under conditions of increased cell turn over - including malignant neoplasms (especially B lymphocytes), inflammation, and some infections. Older studies of patients with multiple myeloma, before treatment, correlated high concentrations of beta-2-m with worse prognosis than observed in patients with myeloma and lower concentrations of beta-2-m. Elevated serum/plasma beta-2-m can be seen with decreased glomerular filtration rate/renal insufficiency. Elevated urine beta-2-m can be seen as a result of impaired proximal tubular reabsorption.

Reference Range *

0 - 2 mg/L

Test Details
Days Set Up
Monday - Friday
Analytic Time

8 hours

Soft Order Code
B2MIC
MiChart Code
Beta 2 Microglobulin
Synonyms
  • B2MIC
  • B2 MICROGLOBULIN
Laboratory
Chemical Pathology
Section
Immunopathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Alternate Specimen
Red top tube
Normal Volume
1.0 mL serum
Minimum Volume
0.5 mL serum
Billing
CPT Code
82232
Fee Code
23373
LOINC
1952-1