Anti-IIa clottable assay
Used for monitoring argatroban therapy.
The concentration in a normal individual is zero. The therapeutic range for argatroban is 0.4 - 1.2 mcg/mL.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Days Test Performed
Daily, 24 hours
Soft Order Code
Argatroban Level, Anti-IIa Inhibitor Assay
Ecarin Clotting Time
Anti-IIa Inhibitor Assay
STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).
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Offsite Collection Instructions
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 4 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, contaminated with heparin or received outside acceptable time limits.
Not to be used for patients on dabigatran therapy.
Full 2.7mL tube or 1mL plasma aliquot
Full 1.8mL tube or 1mL plasma aliquot
Argatroban is a direct thrombin inhibitor used for patients who cannot be treated with Heparin. The initial half-life of Argatroban is between 39-51 minutes and is cleared by the liver. Upon discontinuation of therapy, anticoagulant parameters return to baseline within 2-4 hours.