Test Overview
Test Methodology

Anti-IIa clottable assay

Test Usage

Used for monitoring argatroban therapy.

Reference Range *

The concentration in a normal individual is zero. The therapeutic range for argatroban is 0.4 - 1.2 mcg/mL.

Test Details
Days Set Up
Daily, 24 hours
Analytic Time

2 hours

Soft Order Code
ARGAT
MiChart Code
Argatroban Level, Anti-IIa Inhibitor Assay
Synonyms
  • Argatroban
  • Ecarin Clotting Time
  • ARGAT
  • Anti-IIa Inhibitor Assay
Laboratory
Hematopathology
Section
Coagulation
STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

Specimen Requirements
Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 4 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Rejection Criteria
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, contaminated with heparin or received outside acceptable time limits.
Contraindications
Not to be used for patients on dabigatran therapy.
Blue Top Tube
Normal Volume
Full 2.7mL tube or 1mL plasma aliquot
Minimum Volume
Full 1.8mL tube or 1mL plasma aliquot
Storage Temperature
Room temperature for whole blood or frozen aliquot of citrated plasma.
Additional Information

Argatroban is a direct thrombin inhibitor used for patients who cannot be treated with Heparin. The initial half-life of Argatroban is between 39-51 minutes and is cleared by the liver. Upon discontinuation of therapy, anticoagulant parameters return to baseline within 2-4 hours.

Billing
CPT Code
85130
Fee Code
BA008
LOINC
55363-6
NY State Approved
No