Test Overview

Test Methodology

Anti-IIa clottable assay

Test Usage

Used for monitoring argatroban therapy.

Reference Range*

The concentration in a normal individual is zero. The therapeutic range for argatroban is 0.4 - 1.2 mcg/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

2 hours

Soft Order Code


MiChart Code

Argatroban Level, Anti-IIa Inhibitor Assay



Ecarin Clotting Time
Anti-IIa Inhibitor Assay

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STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 4 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Rejection Criteria

Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, contaminated with heparin or received outside acceptable time limits.


Not to be used for patients on dabigatran therapy.


Blue Top Tube

Normal Volume

Full 2.7mL tube or 1mL plasma aliquot

Minimum Volume

Full 1.8mL tube or 1mL plasma aliquot

Additional Information

Argatroban is a direct thrombin inhibitor used for patients who cannot be treated with Heparin. The initial half-life of Argatroban is between 39-51 minutes and is cleared by the liver. Upon discontinuation of therapy, anticoagulant parameters return to baseline within 2-4 hours.

Billing Information

Fee Codes

CPT Code




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