Test Overview
Test Methodology

Next-generation sequencing is performed to test for the presence of a mutation in all coding regions and intron/exon boundaries of the APC gene. Array comparative genomic hybridization (aCGH) is used to test for the presence of large deletions and duplications.

Test Usage

Confirmation of FAP diagnosis for patients with clinical features.

Reference Range *

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Analytic Time

14 - 28 days

Soft Order Code
MiChart Code
APC Gene, Full Gene Analysis (Sendout)
  • FAP Mutation Screen
  • FAP Large Del/Dup, MLPA
  • DNA Sequence, Follow-up Analysis
  • APCZ
  • Familial Adenomatous Polyposis (FAP) Mutation Screen
  • Adenomatous Polyposis Coli (APC)
  • APC Gene, Full Gene Anlaysis
  • Hereditary Colon Cancer CGH Array (COLAB)
Reference Laboratory
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a lavender top (EDTA) or yellow top (ACD) tube. Invert several times to mix. Send intact specimens stored and transported at room temperature within 48 hours of collection; do not refrigerate or freeze.

Alternate Specimen
20 mL Amniotic fluid refrigerated (do not freeze). All prenatal specimens must be accompanied by a maternal blood specimen.
This test should be ordered only for individuals with symptoms suggestive of FAP. Asymptomatic patients with a family history of FAP should not be tested until a mutation has been identified in an affected family member.
Normal Volume
3 mL EDTA or ACD whole blood
Minimum Volume
1 mL EDTA or ACD whole blood
Additional Information

Hereditary Colon Cancer CGH Array (COLAB) will also be performed and billed at a separate additional charge. Note that FAP mutation analysis should always be preceded and followed by appropriate genetic counseling. By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test sent to Mayo Medical Laboratories.

CPT Code
81201, 81228
Fee Code
AA138, AA209