Test Overview
Test Methodology

Michigan Medicine: Chemiluminescent Immunoassay
Mayo Clinic Laboratories: Enzyme-Linked Immunosorbant Assay (ELISA)

Reference Range *

Females age 12-45 yrs: 0.8 - 9.5 ng/mL, age >45 yrs: <1.0 ng/mL.
AMH performed in the Chemical Pathology Laboratory is measured by the Roche e411 chemiluminescent immunoassay. AMH concentrations in females peak at 25 years and decline with age until menopause. In patients with polycystic ovarian syndrome, AMH concentrations may be 2 to 5 fold higher than age appropriate reference levels. If results are inconsistent with the clinical picture, the Chemical Pathology laboratory at 936-6702.

Testing for all male and female pediatric (age <12 yrs) will be sent to Mayo Clinic Laboratories: Males: age <2 yrs: 14 - 466 ng/mL; age 2-12 yrs: 7.4 - 243 ng/mL; age >12 yrs: 0.7 - 19 ng/mL. Females: age <2 yrs: <4.7 ng/mL; age 2-12 yrs: <8.8 ng/mL.

Test Details
Days Set Up
Daily
Analytic Time

8 hours

Soft Order Code
AMHS
MiChart Code
Anti-Mullerian Hormone (AMH)
Synonyms
  • AMH
  • Mullerian Inhibiting Substance (MIS)
  • Anti Mullerian Hormone
  • Antimullerian Hormone, Serum
Laboratory
Chemical Pathology
Section
Automation
Specimen Requirements
Collection Instructions

Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. Specimen should be collected on days 2-4 of the menstrual cycle. Samples should not be drawn from patients receiving therapy with high biotin doses (>5 mg/day) until at least 8 hours following the last biotin administration.

Alternate Specimen
Red top tube, Lithium Heparin Plasma (Chemical Pathology)
Rejection Criteria
EDTA plasma is not acceptable
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Storage Temperature
Stable 3 days 15-25C, 5 days refrigerated; freeze for longer storage
Additional Information

Only female patients 12 years and older testing will be performed at Michigan Medicine. All male and female patients <12 years testing will be performed by Mayo Clinic Laboratories.
With the Roche methodology (Chemical Pathology), interference was observed at biotin concentrations above 30 ng/mL. Samples should not be drawn from patients receiving therapy with high biotin doses (>5 mg/day) until at least 8 hours following the last biotin administration.

Billing
CPT Code
Michigan Medicine: 82397, Mayo Clinic Laboratories: 83520
Fee Code
Michigan Medicine: JA037, Mayo Clinic Laboratories: 37994
LOINC
Michigan Medicine: 83104-0, Mayo Clinic Laboratories: 38476-8
NY State Approved
No