Detection of naturally occurring IgM antibodies (anti-A and anti-B). May assist in the diagnosis of immune deficiency diseases.
Interpretive report provided.
Infants under twelve months of age frequently have low levels of isohemagglutinins; infants under three months of age may have maternal antibody present. Group AB patients will not have anti-A or anti-B; in these cases screening tests are done for IgM cold autoantibodies.
1 - 72 hours
- Isohemagglutinin Screen
Collect specimen in a pink top tube. Refrigerate and send intact specimen. Specimens are unacceptable if collected in serum separator tube, contaminated, or grossly hemolyzed. Specimens sent for Blood Bank testing cannot be split for use by other laboratories.
Sugar-sugar linkages that confer antigen activity (A,B,H) to the red cell membrane can also occur in biological materials, such as bacteria, viruses, food-stuffs, etc. Anyone with an intact immunological system can react to these naturally-occurring stimuli, resulting in elevated anti-A and/or anti-B titers. Titers may be decreased in congenital agammaglobulinemia and hypogammaglobulinemia. Titration of anti-A/B may be beneficial in the diagnosis of some parasitic infections; indicate this on the requisition.